Cholesterol
Evid Based Complement Alternat Med.2014;2014:459165.
Pterostilbene on metabolic parameters: a randomized, double-blind, and placebo-controlled trial.
Riche DM1, Riche KD2, Blackshear CT3, McEwen CL4, Sherman JJ5, Wofford MR6, Griswold ME7.
Abstract
INTRODUCTION: The purpose of this trial was to evaluate the effect of pterostilbene on metabolic parameters.
METHODS: A prospective, randomized, double-blind, and placebo-controlled study that enrolled 80 patients with a total
RESULTS: LDL increased with pterostilbene monotherapy (17.1 mg/dL; P = 0.001) which was not seen with GE combination (P = 0.47). Presence of a baseline cholesterol medication appeared to attenuate LDL effects. Both systolic (-7.8 mmHg; P < 0.01) and diastolic blood pressure (-7.3 mmHg; P < 0.001) were reduced with high dose pterostilbene. Patients not on cholesterol medication (n = 51) exhibited minor weight loss with pterostilbene (-0.62 kg/m(2); P = 0.012).
CONCLUSION: Pterostilbene increases LDL and reduces blood pressure in adults. This trial is registered with Clinicaltrials.gov NCT01267227.
PMID: 25057276 PMCID: PMC4099343DOI: 10.1155/2014/459165
J Biochem Mol Toxicol.2015 Jan;29(1):35-42. doi: 10.1002/jbt.21604. Epub 2014 Sep 9.
Protective effects of pterostilbene against acetaminophen-induced hepatotoxicity in rats.
El-Sayed el-SM1, Mansour AM, Nady ME.
Abstract
The present study was undertaken to evaluate the protective effect of pterostilbene against acetaminophen-induced hepatotoxicity. Silymarin was used as a standard hepatoprotective agent. A single dose of acetaminophen (800 mg/kg i.p.), injected to male rats, caused significant increases in serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, bilirubin, total cholesterol, triglycerides, tumor necrosis factor alpha, and hepatic contents of malondialdehyde, nitric oxide, caspase-3, hydroxyproline, with significant decreases in serum HDL-cholesterol, total proteins, albumin, and hepatic activities of reduced glutathione, superoxide dismutase and catalase as compared with the control group. On the other hand, administration of each of pterostilbene (50 mg/kg, p.o.) and silymarin (100 mg/kg, p.o.) for 15 days before acetaminophen ameliorated liver function and oxidative stress parameters. Histopathological evidence confirmed the protection offered by pterostilbene from the tissue damage caused by acetaminophen. In conclusion, pterostilbene possesses multimechanistic hepatoprotective activity that can be attributed to its antioxidant, anti-inflammatory, and antiapoptotic actions.
KEYWORDS: Acetaminophen; Antioxidant; Hepatotoxicity; Pterostilbene; Silymarin
PMID: 25201704 DOI: 10.1002/jbt.21604
J Toxicol.2013;2013:463595. doi: 10.1155/2013/463595. Epub 2013 Feb 4.
Analysis of safety from a human clinical trial with pterostilbene.
Riche DM1, McEwen CL, Riche KD, Sherman JJ, Wofford MR, Deschamp D, Griswold M.
Abstract
OBJECTIVES: The purpose of this trial was to evaluate the safety of long-term pterostilbene administration in humans.
METHODOLOGY: The trial was a prospective, randomized, double-blind placebo-controlled intervention trial enrolling patients with hypercholesterolemia (defined as a baseline total cholesterol ≥200 mg/dL and/or baseline low-density lipoprotein cholesterol ≥100 mg/dL). Eighty subjects were divided equally into one of four groups: (1) pterostilbene 125 mg twice daily, (2) pterostilbene 50 mg twice daily, (3) pterostilbene 50 mg + grape extract (GE) 100 mg twice daily, and (4) matching placebo twice daily for 6-8 weeks. Safety markers included biochemical and subjective measures. Linear mixed models were used to estimate primary safety measure treatment effects.
RESULTS: The majority of patients completed the trial (91.3%). The average age was 54 years. The majority of patients were females (71%) and Caucasians (70%). There were no adverse drug reactions (ADRs) on hepatic, renal, or glucose markers based on biochemical analysis. There were no statistically significant self-reported or major ADRs.
CONCLUSION: Pterostilbene is generally safe for use in humans up to 250 mg/day.
PMID: 23431291 PMCID: PMC3575612DOI: 10.1155/2013/463595
Mol Cell Endocrinol.2012 May 15;355(1):25-40. doi: 10.1016/j.mce.2012.01.009. Epub 2012 Jan 16.
Long term induction by pterostilbene results in autophagy and cellular differentiation in MCF-7 cells via ROS dependent pathway.
Chakraborty A1, Bodipati N, Demonacos MK, Peddinti R, Ghosh K, Roy P.
Abstract
This study shows the effect of pterostilbene on intracellular neutral lipid accumulation in MCF-7 breast cancer cells leading to growth arrest and autophagy. On exposing the breast cancer cells with 30 μM pterostilbene for 72 h there was
PMID: 22273805 DOI: 10.1016/j.mce.2012.01.009
J Agric Food Chem.2005 May 4;53(9):3403-7.
Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters.
Rimando AM1, Nagmani R, Feller DR, Yokoyama W.
Abstract
Resveratrol, a stilbenoid antioxidant found in grapes, wine, peanuts
PMID: 15853379 DOI: 10.1021/jf0580364
Cancer Prev Res (Phila).2009 Jul;2(7):650-7. doi: 10.1158/1940-6207.CAPR-08-0224. Epub 2009 Jun 23.
Paul S1, Rimando AM, Lee HJ, Ji Y, Reddy BS, Suh N.
Abstract
Oxidative/nitrosative stress and generation of proinflammatory cytokines are hallmarks of inflammation. Because chronic inflammation is implicated in several pathologic conditions in humans, including cancers of the colon, anti-inflammatory compounds may be useful chemopreventive agents against colon cancer. Stilbenes, such as resveratrol, have diverse pharmacologic activities, which include anti-inflammation, cancer prevention, a cholesterol-lowering effect, enhanced insulin sensitivity, and increased life span. We previously showed that pterostilbene (trans-3,5-dimethoxy-4′-
PMID: 19549798 PMCID: PMC2753521DOI: 10.1158/1940-6207.CAPR-08-0224
Eur J Pharmacol.2016 Apr 15;777:9-16. doi: 10.1016/j.ejphar.2016.02.054. Epub 2016 Feb 24.
Anti-hyperlipidemic and anti-peroxidative role of pterostilbene via Nrf2 signaling in experimental diabetes.
Bhakkiyalakshmi E1, Sireesh D1, Sakthivadivel M2, Sivasubramanian S2, Gunasekaran P2, Ramkumar KM3.
Abstract
Nuclear factor erythroid 2-related factor (Nrf2), a key transcription factor triggers the expression of antioxidant and detoxification genes thereby providing cellular protective functions against oxidative stress-mediated disorders. Recent research has identified that pharmacological activation of Nrf2 also regulates the largest cluster of genes associated with lipid metabolism. With this background, this paper highlights the anti-hyperlipidemic and anti-peroxidative role of pterostilbene (PTS), an Nrf2 activator, in streptozotocin (STZ)-induced diabetic model. PTS administration to diabetic mice for 5 weeks significantly regulated blood glucose levels through the elevation of insulin secretion. The circulatory and liver lipid profiles of total cholesterol (TC), triglycerides (TG) and non-esterified fatty acids (NEFA) were maintained to normal levels upon PTS treatment. Moreover, PTS administration also normalized the circulatory levels of very low-, low- and
KEYWORDS: Diabetes; Dyslipidemia; Lipids; Nrf2; Pterostilbene; Streptozotocin
PMID: 26921755 DOI: 10.1016/j.ejphar.2016.02.054
J Clin Exp Cardiolog.2012 Jun 7;S5:8.
Suppression of Nitric Oxide Production and Cardiovascular Risk Factors in Healthy Seniors and Hypercholesterolemic Subjects by a Combination of Polyphenols and Vitamins.
Qureshi AA1, Khan DA, Mahjabeen W, Papasian CJ, Qureshi N.
Abstract
BACKGROUND: Dysregulated immune function associated with
AIMS: To determine whether serum nitric oxide (NO) levels increase with age in humans, and whether the combined cholesterol-lowering and inflammation-reducing properties of resveratrol, pterostilbene,
METHODS: Elderly human subjects were stratified into two groups based on total serum cholesterol levels. Initial total serum cholesterol levels were normal and elevated in Group 1 and 2 subjects, respectively. Baseline serum NO, C-reactive protein (CRP), γ-glutamyltransferase (γ-GT) activity, uric acid, total antioxidant status (TAS), total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglycerides levels were established over a four week period. Group 1 subjects subsequently received nutritional supplementation with one of two different combinations (NS-7 = 25 mg of each, resveratrol, pterostilbene, quercetin, δ-tocotrienol, nicotinic acid, morin hydrate or NS-6 = morin hydrate replaced with quercetin, 50 mg/capsule). Group 2 subjects also received these nutritional supplements (two capsules/d), but an AHA Step-1 diet was also implemented. After these interventions were administered for four weeks, the above parameters were re-measured and changes from baseline levels determined. Nitric acid (NO) levels in children, young adults, and seniors were also compared.
RESULTS: The key results of the current study were: 1) that serum NO levels were significantly increased in seniors compared to both children (~80%) and young adults (~65%); 2) that the intake of two capsules/d of NS-7 or NS-6 for four weeks significantly (P < 0.05) decreased serum NO (39%, 24%), CRP (19%, 21%), uric acid (6%, 12%) levels, and γ-GT activity (8%, 6%), respectively in free-living healthy seniors; 3) that serum NO (36%, 29%), CRP (29%, 20%), uric acid (6%, 9%) γ-GT activity (9%, 18%), total cholesterol (8%, 11%), LDL-cholesterol (10%, 13%), and triglycerides (16%, 23%) levels were significantly (P < 0.02) decreased in hypercholesterolemic subjects restricted to AHA Step-1 diet plus intake of SN-7 or SN-6 (two capsules/d), respectively; 4) that TAS was increased (3%, 9%; P < 0.05) in free-living healthy seniors receiving NS-7 or NS-6 alone, and in hypercholesterolemic subjects plus AHA Step-1 diet (20%, 12%; P < 0.02) with either of the combinations tested.
CONCLUSIONS: Serum NO levels are elevated in elderly humans compared to children or young adults. Diet supplementation with combinations of resveratrol, pterostilbene, morin hydrate, quercetin, δ-tocotrienol, riboflavin, and nicotinic acid reduce cardiovascular risk factors in humans when used as nutritional supplements with, or without, other dietary changes.
PMID: 23125945 PMCID: PMC3486425DOI: 10.4172/2155-9880.S5-008
Bioorg Med Chem.2008 Apr 1;16(7):3800-8. doi: 10.1016/j.bmc.2008.01.051. Epub 2008 Jan 31.
Design, synthesis, biological evaluation and docking studies of pterostilbene analogs inside PPARalpha.
Mizuno CS1, Ma G, Khan S, Patny A, Avery MA, Rimando AM.
Abstract
Pterostilbene, a naturally occurring analog of resveratrol, has previously shown PPARalpha activation in H4IIEC3 cells and was found to decrease cholesterol levels in animals. In this study, analogs of pterostilbene were synthesized and their ability to activate PPARalpha was investigated. Among analogs that
PMID: 18272370 DOI: 10.1016/j.bmc.2008.01.051
J Clin Exp Cardiolog.2013 Mar 2;4(3). pii: 238.
Nutritional Supplement-5 with a Combination of Proteasome Inhibitors (Resveratrol, Quercetin, δ-Tocotrienol) Modulate Age-Associated Biomarkers and Cardiovascular Lipid Parameters in Human Subjects.
Qureshi AA1, Khan DA, Mahjabeen W, Papasian CJ, Qureshi N.
Abstract
BACKGROUND: Age-associated altered redox imbalances and dysregulated immune function, contribute to the development of a variety of
METHODS: Two
RESULTS: All the subjects completed each phase in both studies without any complaints. There were significant ( P< 0.01 – 0.05) decreases in the serum levels of NO (30%, 26%), CRP (29%, 21%), γ-GT activity (14%, 17%), and blood pressure (systolic/diastolic, 3/6%, 3/3%) of Groups A and B, respectively, of free-living healthy seniors without affecting the total, HDL-, LDL-cholesterol or triglycerides compared to their respective baseline values. However, serum levels of NO (36%, 43%), CRP (31%, 48%), γ-GT (17%, 20%), total cholesterol (19%, 15%), LDL-cholesterol (28%, 20%), triglycerides (11%, 18%) of Groups C and D were significantly ( P< 0.01-0.05) decreased with NS-5 treatment of hypercholesterolemic subjects compared to baseline values, without affecting the serum HDL-cholesterol levels. The serum levels of total antioxidant status (TAS) were increased (10%, 14%; P< 0.05) in Groups A and B, increased (19%, 24%; P< 0.02), and blood pressure (systolic/diastolic, 5/6%, 3/5%) in Groups C and D with NS-5 treatment, compared to respective baseline values.
CONCLUSIONS: The consumption of NS-5 mixture decreased significantly serum NO, CRP and γ-GT levels, improved TAS and lipid profiles at risk cardiovascular and hold promise for delaying
KEYWORDS: Anti-inflammatory and anti-ageing agents; C-reactive protein (CRP); Nitric oxide (NO); Quercetin; Resveratrol; Total antioxidant status (TAS); γ-glutamyl-transferase (γ-GT); δ-tocotrienol
PMID: 24319627 PMCID: PMC3851026DOI: 10.4172/2155-9880.1000238
J Ethnopharmacol.1999 Dec 15;68(1-3):71-6.
Paul B1, Masih I, Deopujari J, Charpentier C.
Abstract
‘Darakchasava’ is a well known Indian herbal preparation of which the main ingredient is Vitis vinifera L. This ‘ayurvedic’ medicine is prescribed as a cardiotonic and also given for other disorders. HPLC analysis of this
PMID: 10624864
Nat Prod Res.2015;29(24):2332-5.
Chemical
Hanif MA1,2, Al-Maskari AY2, Al-Sabahi JN3, Al-Hdhrami I2, Khan MM2, Al-Azkawi A4, Hussain AI5.
Abstract
Medicago sativa Linn growing in Omani desert were chemically
KEYWORDS: GC; HPLC; ICP analysis; Medicago sativa; medical plant
PMID: 25674815 DOI: 10.1080/14786419.2015.1008474
Lipids Health Dis.2016 Sep 9;15:151. doi: 10.1186/s12944-016-0323-3.
Synergistic combinatorial antihyperlipidemic study of selected natural antioxidants; modulatory effects on lipid profile and endogenous antioxidants.
Hannan PA1, Khan JA2, Ullah I1, Ullah S1.
Abstract
BACKGROUND: Hyperlipidemia, a major pathological condition associated with disrupted lipid levels and physiological redox homeostasis. The excessive release of reactive oxygen species (ROS) leads to enhanced lipid peroxidation, aggravated atherosclerosis
METHODS: Antihyperlipidemic effects of selected natural antioxidants; the phenolic oligomeric proanthocyanidins (OPC) and pterostilbene (PT) with niacin (NA) were investigated in
RESULTS: The results showed synergistic effects of low dose antioxidant blends. Therapies retarded elevation in blood lipid levels, lipid peroxidation
CONCLUSION: This study provides
KEYWORDS: Atherosclerosis; Hyperlipidemia; Lipid peroxidation; Redox homeostasis; Synergism
PMID: 27613388 PMCID: PMC5016891DOI: 10.1186/s12944-016-0323-3
Planta Med.2008 Oct;74(13):1635-43. doi: 10.1055/s-0028-1088301. Epub 2008 Oct 8.
Biological/chemopreventive activity of stilbenes and their effect on colon cancer.
Rimando AM1, Suh N.
Abstract
Colon cancer is one of the leading causes of cancer death in men and women in Western countries. Epidemiological studies have linked the consumption of fruits and vegetables to a reduced risk of colon cancer, and small fruits are particularly rich sources of many active phytochemical stilbenes, such as resveratrol and pterostilbene. Recent advances in the prevention of colon cancer have stimulated an interest in diet and lifestyle as an effective means of intervention. As constituents of small fruits such as grapes, berries
PMID: 18843589 DOI: 10.1055/s-0028-1088301