Cancer Stem Cells
Mol Nutr Food Res.2013 Jul;57(7):1123-34. doi: 10.1002/mnfr.201200549. Epub 2013 Mar 15.
Pterostilbene, a bioactive component of blueberries, suppresses the generation of breast cancer stem cells within
Mak KK1
Abstract
SCOPE: Tumor-associated macrophages (TAMs) have been shown to promote metastasis and malignancy. Pterostilbene, a natural stilbene isolated from blueberries, has been suggested for anti-cancer effects. Here, we explored the potential cancer stem cells (CSCs)/TAM modulating effects of pterostilbene in breast cancer.
METHODS AND RESULTS: Using
CONCLUSION: Pterostilbeneeffectively suppresses the generation of CSCs and metastatic potential under the influence of M2 TAMs via modulating EMT associated signaling pathways, specifically
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
KEYWORDS: Breast cancer stem cells; Epithelial-to-mesenchymal transition; Pterostilbene; Tumor-associated macrophages; miR448
PMID: 23504987
Evid Based Complement Alternat Med.2013;2013:258425.
BlueBerry Isolate, Pterostilbene, Functions as a Potential Anticancer Stem Cell Agent in Suppressing Irradiation-Mediated Enrichment of Hepatoma Stem Cells.
Lee CM1, Su YH, Huynh TT, Lee WH, Chiou JF, Lin YK, Hsiao M, Wu CH, Lin YF, Wu AT, Yeh CT.
Abstract
For many malignancies, radiation therapy remains the second option only to surgery in terms of its curative potential. However, radiation-induced tumor cell death is limited by a number of factors, including the adverse response of the tumor microenvironment to the treatment and either intrinsic or acquired mechanisms of evasive resistance, and the existence of cancer stem cells (CSCs). In this study, we demonstrated that using different doses of irradiation led to the enrichment of CD133(+) Mahlavu cells using
PMID: 23878592
J Agric Food Chem.2015 Mar 11;63(9):2432-41. doi: 10.1021/acs.jafc.5b00002. Epub 2015 Feb 25.
Targeting cancer stem cells in breast cancer: potential anticancer properties of 6-
Wu CH1
Abstract
Breast cancer stem cells (BCSCs) constitute a small fraction of the primary tumor that can self-renew and become a drug-resistant cell population, thus limiting the treatment effects of chemotherapeutic drugs. The present study evaluated the cytotoxic effects of five phytochemicals including 6-gingerol (6-G), 6-
KEYWORDS: 6-
PMID: 25686711
J Nutr Biochem.2015 May;26(5):466-75.
Pterostilbene suppressed irradiation-resistant glioma stem cells by modulating GRP78/miR-205 axis.
Huynh TT1
Abstract
Glioblastoma multiforme (GBM) is the most aggressive type characterized by relapse and resistance even with the combination of radio- and chemotherapy. The presence of glioma stem cells (GSCs) has been shown to contribute to tumorigenesis, recurrence
Copyright © 2015 Elsevier Inc. All rights reserved.
KEYWORDS: CD133+ glioma stem cells; Glucose-regulated protein, 78 kDa (GRP78); Irradiation resistance; Pterostilbene; miR-205
PMID: 25736407
Oncotarget.2016 Jun 28;7(26):39363-39375. doi: 10.18632/oncotarget.8101.
Modulation of macrophage polarization and lung cancer cell stemness by MUC1 and development of a related small-molecule inhibitor pterostilbene.
Huang WC1,2,3,Chan ML1,2,3, Chen MJ3,4, Tsai TH1,5, Chen YJ1,6,3,7.
Abstract
Tumor-associated macrophages (TAMs) polarized to the M2 phenotype play key roles in tumor progression in different cancer types, including lung cancer. MUC1 expression in various types of cancer is an indicator of poorer prognosis. Elevated MUC1 expression has been reported in inflammatory lung macrophages and is associated with lung cancer development. Here, we investigated the role of M2-polarized TAMs (M2-TAMs) in the generation of lung cancer stem cells (LCSCs) and tested pterostilbene, a small-molecule agent that modulates MUC1 expression in lung cancer cells, with the goal of subverting the microenvironment toward a favorable anti-tumor impact. We found that MUC1 was overexpressed in lung cancer patients, which was associated with poor survival rates. M2-TAMs and cancer cell lines were co-cultured in an experimental tumor microenvironment model. The expression levels of MUC1 and cancer stemness genes significantly increased in lung cancer cells in the presence of the M2-TAM cells. Intriguingly, pterostilbene dose-dependently suppressed self-renewal ability in M2-TAMs-co-cultured lung cancer cells, and this suppression was accompanied by downregulation of MUC1, NF-κB, CD133, β-catenin, and Sox2 expression. Moreover, MUC1-silenced M2-TAMs exhibited a significantly lower ability to promote LCSC generation and decreased levels of NF-κB, CD133, and Sox2. The results suggest that MUC1 plays an important role in TAM-induced LCSC progression. Pterostilbene may have therapeutic potential for modulating the unfavorable effects of TAMs in lung cancer progression.
KEYWORDS: Immune response; Immunity; Immunology and Microbiology Section; M2 polarization; MUC1; lung cancerstem cells (CSCs); pterostilbene; tumor-associated macrophages (TAMs)
PMID: 27276704