NanoStilbene

a nanoparticle formulation of pterostilbene

NanoStilbene PK Study

NanoStilbene Administration Results in Superior Pharmacokinetic Profi­le Compared to Pterostilbene Administration

NanoStilbene Clinical Trial in Cancer

These results suggest that NanoStilbene may be a useful adjuvant to immunotherapy of cancer rescuing T cell and NK cell activities.

Pterostilbene Literature Review

Cancer and Pterostilbene Comprehensive Literature Review

Paper of Interest

J Agric Food Chem.2002 Jun 5;50(12):3453-7.
Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol.
Rimando AM1, Cuendet M, Desmarchelier C, Mehta RG, Pezzuto JM, Duke SO.

Abstract
Pterostilbene, a natural methoxylated analogue of resveratrol, was evaluated for antioxidative potential. The peroxyl-radical scavenging activity of pterostilbene was the same as that of resveratrol, having total reactive antioxidant potentials of 237 +/- 58 and 253 +/- 53 microM, respectively. Both compounds were found to be more effective than Trolox as free radical scavengers. Using a plant system, pterostilbene also was shown to be as effective as resveratrol in inhibiting electrolyte leakage caused by herbicide-induced oxidative damage, and both compounds had the same activity as alpha-tocopherol. Pterostilbene showed moderate inhibition (IC50 = 19.8 microM) of cyclooxygenase (COX)-1, and was weakly active (IC50 = 83.9 microM) against COX-2, whereas resveratrol strongly inhibited both isoforms of the enzyme with IC50 values of approximately 1 microM. Using a mouse mammary organ culture model, carcinogen-induced preneoplastic lesions were, similarly to resveratrol, significantly inhibited by pterostilbene (ED50 = 4.8 microM), suggesting antioxidant activity plays an important role in this process.

PMID: 12033810

Gut Microbiota

 

Mol Nutr Food Res.2017 Jan;61(1). doi: 10.1002/mnfr.201500906. Epub 2016 Aug 3.

Pterostilbene-induced changes in gut microbiota composition in relation to obesity.

Etxeberria U1, Hijona E2,3, Aguirre L4,5, Milagro FI1,4, Bujanda L2,3, Rimando AM6, Martínez JA1,4, Portillo MP4,5.

Author information

Abstract

SCOPE: Nutritional interventions based on the use of natural bioactive compounds might offer new possibilities for reshaping obesity-associated bacterial dysregulation or dysbiosis and improving health. We evaluated whether pterostilbene supplementation could induce changes in gut microbiota composition and whether these modifications were associated with improvements in metabolic variables.

METHODS AND RESULTS: Zucker (fa/fa) rats were given a standard diet supplemented (n = 10) or not (n = 9) with pterostilbene (15 mg/kg body weight/day) by oral gavage for 6 weeks. Faucal samples at the beginning and at the end of the intervention period were analyzed by Illumina Mi-Seq sequencing approach. Pterostilbene exerted protective antiobesity effects, improved metabolic function (insulin sensitivity), and induced structural changes in gut microbiota composition. A decrease in the levels of Firmicutes and an increase in Verrucomicrobia phyla were detected in the pterostilbene-treated group. Bacterial species belonging to genera Akkermansia and Odoribacter were also increased. A strong inverse correlation between Akkermansia muciniphila and body weight was evidenced. Odoribacter splanchnicus showed a negative correlation with adiposity.

CONCLUSION: Pterostilbene modifies intestinal bacteria composition toward a healthier microbial profile and suggests that the antiobesity effects induced in Zucker rats could be associated with an enrichment of the mucin-degrading bacterial members, namely Akkermansia and Odoribacter genus.

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KEYWORDS: Akkermansia; Insulin sensitivity; Odoribacter; Polyphenols; Verrucomicrobia

PMID: 27377854 DOI: 10.1002/mnfr.201500906

Frequently Asked Questions

Learn More About It!

What is Pterostilbene?

Pterostilbene is a natural dietary compound found in blueberries. We use the syntheic version due to limited amounts occuring naturally in the berries.

how much nanostilbene should i take daily?

We recommend up to 300mg daily which is approx 1.5 milliliters. However many find that 200mg daily is also suffice, therefore a range of 200-300mg daily is recommended.

can it be applied topically?

Yes small amounts may be applied locally but remember at 200mg per ml it is highly concentrated with a single drop containing 10mg.

What is nanostilbene?

NanoStilbene  is an easily absorbed nanoemulsion of nanoparticle pterostilbene in the range of 75-100nm at a concentration of 200 milligrams per milliliter

what is the concentration of nanostilbene?

NanoStilbene contains 200mg per ml or approximately 10mg per drop.

where can i obtain nanostilbene?

NanoStilbene can be obtained at our e-commerce site.