NanoStilbene

a nanoparticle formulation of pterostilbene

NanoStilbene PK Study

NanoStilbene Administration Results in Superior Pharmacokinetic Profi­le Compared to Pterostilbene Administration

NanoStilbene Clinical Trial in Cancer

These results suggest that NanoStilbene may be a useful adjuvant to immunotherapy of cancer rescuing T cell and NK cell activities.

Pterostilbene Literature Review

Cancer and Pterostilbene Comprehensive Literature Review

Paper of Interest

J Agric Food Chem.2002 Jun 5;50(12):3453-7.
Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol.
Rimando AM1, Cuendet M, Desmarchelier C, Mehta RG, Pezzuto JM, Duke SO.

Abstract
Pterostilbene, a natural methoxylated analogue of resveratrol, was evaluated for antioxidative potential. The peroxyl-radical scavenging activity of pterostilbene was the same as that of resveratrol, having total reactive antioxidant potentials of 237 +/- 58 and 253 +/- 53 microM, respectively. Both compounds were found to be more effective than Trolox as free radical scavengers. Using a plant system, pterostilbene also was shown to be as effective as resveratrol in inhibiting electrolyte leakage caused by herbicide-induced oxidative damage, and both compounds had the same activity as alpha-tocopherol. Pterostilbene showed moderate inhibition (IC50 = 19.8 microM) of cyclooxygenase (COX)-1, and was weakly active (IC50 = 83.9 microM) against COX-2, whereas resveratrol strongly inhibited both isoforms of the enzyme with IC50 values of approximately 1 microM. Using a mouse mammary organ culture model, carcinogen-induced preneoplastic lesions were, similarly to resveratrol, significantly inhibited by pterostilbene (ED50 = 4.8 microM), suggesting antioxidant activity plays an important role in this process.

PMID: 12033810

Ovarian Cancer

Eur J Gynaecol Oncol.2016;37(3):342-7.

Pterostilbene induces apoptosis through caspase activation in ovarian cancer cells.

Dong J, Guo H, Chen Y.

Abstract

AIM: Pterostilbene, an analog of resveratrol increasing bioavailability has shown to offer antioxidant and anticancer properties in vitro and in vivo. Dietary compounds with anti-oxidant properties have been shown to gain importance due to therapeutic applications. In addition, compounds with higher bioavailability levels show great interest in present scenario. Thus, the present study aimed at investigating the cytotoxic role of pterostilbeneand its mechanism of cell death in ovarian cancercells line.

MATERIALS AND METHODS: The effect of pterostilbenewas determined on SKOV-3 cells, by cytotoxicity assays, oxidative stress levels, [Ca2+]i levels, mitochondrial depolarization, cell cycle analysis and caspase 3, 8, and 9 activities.

RESULTS: The study revealed that pterostilbene offered cytotoxic effect at a concentration of IC50-55 uM. Further, pterostilbene induced reactive oxygen species (ROS) mediated intrinsic pathway of apoptosis through enhancing oxidative stress, [Ca2+]i levels, mitochondrial depolarization, Sub G1 accumulation, and activation of caspase 3 and 9.

CONCLUSION: The study demonstrates for the first time the cytotoxic potential of pterostilbene against ovarian cancercells.

PMID: 27352561


Med Sci Monit.2017 Jun 30;23:3192-3199.

Anticancer Activity of Pterostilbene in Human Ovarian Cancer Cell Lines.

Pei HL1, Mu DM2, Zhang B2.

Author information

Abstract

BACKGROUND Epithelial ovarian cancer is a major cause of mortality in women and one of the most common gynecologic disorders. Pterostilbene (PTS), a trans-3,5-dimethoxy-4′-hydroxystilbene, was chosen for this work due to its reported effectiveness as a chemotherapeutic agent in cancer studies. In this work, we studied underlying molecular mechanisms of PTS treatment in various ovarian cancer cell lines such as OVCAR8, OV1063, IGROV-1, and SKOV3. MATERIAL AND METHODS We used the cytometric bead array (CBA) method and real-time PCR analysis to analyze the secretion level of tumor necrosis factor alpha (TNF-α) and to measure the TNF-α mRNA expression. NF-kappa B (NF-κB) promoter analysis, Western blot analysis, electrophoresis mobility shift assay (EMSA), and immunostaining analyses were performed to measure the NF-κB activity and other relative proteins levels. RESULTS The PTS treatment decreased the release of TNF-α in IGROV-1 ovarian cancer cells. It also showed significant inhibitory effect on nuclear NF-κB p50, and NF-κB p65 protein levels. CONCLUSIONS From the results obtained, we suggest that PTS has the potential to treat ovarian cancer by reducing the level of TNF-α cytokine and to have a limited effect on NF-κB, AKT, and ERK signaling pathways.

PMID: 28664898

Frequently Asked Questions

Learn More About It!

What is Pterostilbene?

Pterostilbene is a natural dietary compound found in blueberries. We use the syntheic version due to limited amounts occuring naturally in the berries.

how much nanostilbene should i take daily?

We recommend up to 300mg daily which is approx 1.5 milliliters. However many find that 200mg daily is also suffice, therefore a range of 200-300mg daily is recommended.

can it be applied topically?

Yes small amounts may be applied locally but remember at 200mg per ml it is highly concentrated with a single drop containing 10mg.

What is nanostilbene?

NanoStilbene  is an easily absorbed nanoemulsion of nanoparticle pterostilbene in the range of 75-100nm at a concentration of 200 milligrams per milliliter

what is the concentration of nanostilbene?

NanoStilbene contains 200mg per ml or approximately 10mg per drop.

where can i obtain nanostilbene?

NanoStilbene can be obtained at our e-commerce site.