NanoStilbene

a nanoparticle formulation of pterostilbene

NanoStilbene PK Study

NanoStilbene Administration Results in Superior Pharmacokinetic Profi­le Compared to Pterostilbene Administration

NanoStilbene Clinical Trial in Cancer

These results suggest that NanoStilbene may be a useful adjuvant to immunotherapy of cancer rescuing T cell and NK cell activities.

Pterostilbene Literature Review

Cancer and Pterostilbene Comprehensive Literature Review

Paper of Interest

J Agric Food Chem.2002 Jun 5;50(12):3453-7.
Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol.
Rimando AM1, Cuendet M, Desmarchelier C, Mehta RG, Pezzuto JM, Duke SO.

Abstract
Pterostilbene, a natural methoxylated analogue of resveratrol, was evaluated for antioxidative potential. The peroxyl-radical scavenging activity of pterostilbene was the same as that of resveratrol, having total reactive antioxidant potentials of 237 +/- 58 and 253 +/- 53 microM, respectively. Both compounds were found to be more effective than Trolox as free radical scavengers. Using a plant system, pterostilbene also was shown to be as effective as resveratrol in inhibiting electrolyte leakage caused by herbicide-induced oxidative damage, and both compounds had the same activity as alpha-tocopherol. Pterostilbene showed moderate inhibition (IC50 = 19.8 microM) of cyclooxygenase (COX)-1, and was weakly active (IC50 = 83.9 microM) against COX-2, whereas resveratrol strongly inhibited both isoforms of the enzyme with IC50 values of approximately 1 microM. Using a mouse mammary organ culture model, carcinogen-induced preneoplastic lesions were, similarly to resveratrol, significantly inhibited by pterostilbene (ED50 = 4.8 microM), suggesting antioxidant activity plays an important role in this process.

PMID: 12033810

Bladder Cancer

 

Mol Nutr Food Res.2010 Dec;54(12):1819-32. doi: 10.1002/mnfr.201000067.

Pterostilbene induces autophagy and apoptosis in sensitive and chemoresistant human bladder cancer cells.

Chen RJ1,Ho CT, Wang YJ.

Author information

Abstract

SCOPE: Bladder cancer is one of the most common malignancies in the world. The majority of bladder cancer deaths are due to unresectable lesions that are resistant to chemotherapy. Pterostilbene(PT), a naturally occurring phytoalexin, possesses a variety of pharmacologic activities, including antioxidant, cancer prevention activity and cytotoxicity to many cancers. We found that PT effectively inhibits the growth of sensitive and chemoresistant human bladder cancer cells by inducing cell cycle arrest, autophagy and apoptosis. Down-regulations of Cyclin A, B and D1 and pRB are the results of PT-induced cell cycle arrest.

METHODS AND RESULTS: Autophagy occurred at an early stage and was observed through the formation of acidic vesicular organelles (the marker for autophagy) and microtubule-associated protein 1 light chain 3-II production. Apoptosis occurred at a later stage and was detected by Annexin V and 4′,6-diamidino-2-phenylindole staining. PT-induced autophagy was triggered by the inhibition of active human protein kinase/the mammalian TOR/p70S6K pathway and activation of extracellular signal-regulated kinase pathway. Inhibition of autophagy by pretreatment with 3-methyladenine, bafilomycin A1, Beclin 1 or extracellular signal-regulated kinase short hairpin RNA enhanced PT-triggered apoptosis.

CONCLUSION: This is the first study to demonstrate that PT causes autophagy in cancer cells and suggests that PT could serve as a new and promising agent for the treatment of sensitive and chemoresistant bladder cancer cells.

Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PMID: 20603834

Frequently Asked Questions

Learn More About It!

What is Pterostilbene?

Pterostilbene is a natural dietary compound found in blueberries. We use the syntheic version due to limited amounts occuring naturally in the berries.

how much nanostilbene should i take daily?

We recommend up to 300mg daily which is approx 1.5 milliliters. However many find that 200mg daily is also suffice, therefore a range of 200-300mg daily is recommended.

can it be applied topically?

Yes small amounts may be applied locally but remember at 200mg per ml it is highly concentrated with a single drop containing 10mg.

What is nanostilbene?

NanoStilbene  is an easily absorbed nanoemulsion of nanoparticle pterostilbene in the range of 75-100nm at a concentration of 200 milligrams per milliliter

what is the concentration of nanostilbene?

NanoStilbene contains 200mg per ml or approximately 10mg per drop.

where can i obtain nanostilbene?

NanoStilbene can be obtained at our e-commerce site.