NanoStilbene Administration Results in Superior Pharmacokinetic Profile Compared to Pterostilbene Administration
These results suggest that NanoStilbene may be a useful adjuvant to immunotherapy of cancer rescuing T cell and NK cell activities.
Paper of Interest
Folia Histochem Cytobiol.2012;50(4):574-80. doi: 10.5603/20257.
Pterostilbene induces cell cycle arrest and apoptosis in MOLT4 human leukemia cells.
Siedlecka-Kroplewska K1, Jozwik A, Kaszubowska L, Kowalczyk A, Boguslawski W.
Pterostilbene, a polyphenolic compound present in grapes and other fruits, has been demonstrated to inhibit growth and induce apoptosis and autophagy in some cancer cell types. We found that pterostilbene at the IC(90) concentration of 44 µM inhibited proliferation and induced apoptosis in MOLT4 human leukemia cells. Treatment with pterostilbene resulted in a transient accumulation of cells in the G(0)/G(1)-cell cycle phase followed by the S-phase arrest. Pterostilbene-induced apoptotic death of MOLT4 cells was mediated by caspase-3 activation and was accompanied by the disruption of mitochondrial membrane potential, phosphatidylserine externalization
Int J Biochem Cell Biol.2005 Aug;37(8):1709-26. Epub 2005 Apr 26.
Pterostilbene and 3′-
Pterostilbene and 3,5-
J Toxicol Sci.2012 Feb;37(1):13-21.
A series of 22 stilbene derivatives based on resveratrol were synthesized incorporating acetoxy-, benzyloxy-, carboxy-, chloro-, hydroxy- and methoxy functional groups. We examined the cytotoxicity of these 22 stilbenes in human K562 chronic myelogenous leukemia cells. Only four compounds were cytotoxic namely 4′-hydroxy-3-
J Physiol Pharmacol.2013 Oct;64(5):545-56.
Pterostilbene induces accumulation of autophagic vacuoles followed by cell death in HL60 human leukemia cells.
Pterostilbene, a naturally occurring structural analog of resveratrol, has been reported to exert antiproliferative and proapoptotic effects in various cancer types. Recently, it has been demonstrated to induce both autophagy and apoptosis in human bladder and breast cancer cell lines. The aim of this study was to evaluate the effects of pterostilbene on HL60 human leukemia cells. Cell morphology was examined using confocal and electron microscopy. Cell viability was determined by MTT, neutral red uptake
PLoS One.2014 Aug 21;9(8):e105342. doi: 10.1371/journal.pone.0105342. eCollection 2014.
Pterostilbenesimultaneously induced G0/G1-phase arrest and MAPK-mediated mitochondrial-derived apoptosis in human acute myeloid leukemia cell lines.
BACKGROUND: Pterostilbene(PTER) is a dimethylated analog of the phenolic phytoalexin, resveratrol, with higher anticancer activity in various tumors. Herein, the molecular mechanisms by which PTER exerts its anticancer effects against acute myeloid leukemia (AML) cells were investigated.
METHODOLOGY AND PRINCIPAL FINDINGS: Results showed that PTER suppressed cell proliferation in various AML cell lines.
CONCLUSION: Taken together, our results suggest that PTER induced HL-60 cell death via MAPKs-mediated mitochondria apoptosis pathway and loss of LMP might be another cause for cell apoptosis induced by PTER.
Sci Rep.2016 Nov 21;6:37417. doi: 10.1038/srep37417.
Pterostilbene induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma cells.
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL). Pterostilbene, a natural dimethylated analog of resveratrol, has been shown to possess diverse pharmacological activities, including anti-inflammatory, antioxidant and anticancer properties. However, to the best of our knowledge, there has been no study of the effects of pterostilbene upon hematological malignancies. Herein, we report the antitumor activity and mechanism of pterostilbene against DLBCL cells both in vitro and in vivo. We found that pterostilbene treatment resulted in a dose-dependent inhibition of cell viability. In addition, pterostilbene exhibited a strong cytotoxic effect, as evidenced not only by reductions of mitochondrial membrane potential (MMP) but also by increases in cellular apoptotic index and reactive oxygen species (ROS) levels, leading to arrest in the S-phase of the cell cycle. Furthermore, pterostilbene treatment directly up-regulated p-p38MAPK and down-regulated p-ERK1/2. In vivo, intravenous administration of pterostilbene inhibited tumor development in xenograft mouse models. Overall, the results suggested that pterostilbene is a potential anti-cancer pharmaceutical against human DLBCL by a mechanism involving the suppression of ERK1/2 and activation of p38MAPK signaling pathways.
Int J Mol Sci.2016 Nov 17;17(11). pii: E1927.
PterostilbeneInhibits Human Multiple Myeloma Cells via ERK1/2 and JNK Pathway In Vitro and In Vivo.
KEYWORDS: ERK1/2; JNK; apoptosis; cell cycle; multiple myeloma; pterostilbene
Frequently Asked Questions
Learn More About It!
What is Pterostilbene?
Pterostilbene is a natural dietary compound found in blueberries. We use the syntheic version due to limited amounts occuring naturally in the berries.
how much nanostilbene should i take daily?
We recommend up to 300mg daily which is approx 1.5 milliliters. However many find that 200mg daily is also suffice, therefore a range of 200-300mg daily is recommended.
can it be applied topically?
Yes small amounts may be applied locally but remember at 200mg per ml it is highly concentrated with a single drop containing 10mg.
What is nanostilbene?
NanoStilbene is an easily absorbed nanoemulsion of nanoparticle pterostilbene in the range of 75-100nm at a concentration of 200 milligrams per milliliter
what is the concentration of nanostilbene?
NanoStilbene contains 200mg per ml or approximately 10mg per drop.
where can i obtain nanostilbene?
NanoStilbene can be obtained at our e-commerce site.