NanoStilbene Administration Results in Superior Pharmacokinetic Profile Compared to Pterostilbene Administration
These results suggest that NanoStilbene may be a useful adjuvant to immunotherapy of cancer rescuing T cell and NK cell activities.
Paper of Interest
Astragalus, a commonly used traditional Chinese medicine, has exhibited antitumor actions in patients. In this study, in vitro and in vivo antitumor effects of astragalus and synergistic antitumor efficacy in combination with pterostilbene were investigated. Melanoma cells were treated with pterostilbene (Pt), graduated doses of astragalus injection (AI), or these in combination. Cell viability was measured using
Association between pterostilbene and quercetin inhibits
Inhibition of cancer growth by resveratrol (trans-3,5,4′-trihydroxystilbene; RESV), a phytoalexin present in many plant species, is limited by its low bioavailability. Pterostilbene (3,5-dimethoxy-4′-
J Biol Chem.2007 Feb 2;282(5):2880-90. Epub 2006 Nov 29.
Nitric oxide mediates natural polyphenol-induced Bcl-2 down-regulation and activation of cell death in metastatic B16 melanoma.
Intravenous administration to mice of trans-pterostilbene (t-
Am J Surg.2009 Nov;198(5):679-84. doi: 10.1016/j.amjsurg.2009.07.014.
BACKGROUND: Pterostilbene and inositol-6-phosphate (IP6) have been shown to inhibit melanoma growth in vitro. However, pterostilbene’s mechanism of action has not been clearly demonstrated. We aimed to further investigate the mechanism of action for
METHODS: Melanoma cells were treated with increasing doses of pterostilbene, IP6, or combinations thereof. Cell viability was measured at 24 hours, 48 hours, and 72 hours using
CONCLUSIONS: Pterostilbeneproduces caspase-dependent apoptosis in melanoma cell lines. Combination treatment with IP6 produces synergistic growth inhibition. Both compounds have significant potential for a therapeutic role in the treatment of melanoma.
Antioxid Redox Signal.2016 Jun 10;24(17):974-90. doi: 10.1089/ars.2015.6437. Epub 2016 Mar 15.
PterostilbeneDecreases the Antioxidant Defenses of Aggressive Cancer Cells In Vivo: A Physiological Glucocorticoids- and Nrf2-Dependent Mechanism.
AIMS: Polyphenolic phytochemicals have anticancer properties. However, in mechanistic studies, lack of correlation with the bioavailable concentrations is a critical issue. Some reports had suggested that these molecules downregulate the stress response, which may affect growth and the antioxidant protection of malignant cells. Initially, we studied this potential underlying mechanism using different human melanomas (with genetic backgrounds correlating with most melanomas), growing in nude mice as xenografts, and pterostilbene(
RESULTS: Intravenous administration of
INNOVATION: Although bioavailability-related limitations may preclude direct anticancer effects in vivo, natural polyphenols may also interfere with the growth and defense of cancer cells by downregulating the pituitary gland-dependent ACTH synthesis.
Frequently Asked Questions
Learn More About It!
What is Pterostilbene?
Pterostilbene is a natural dietary compound found in blueberries. We use the syntheic version due to limited amounts occuring naturally in the berries.
how much nanostilbene should i take daily?
We recommend up to 300mg daily which is approx 1.5 milliliters. However many find that 200mg daily is also suffice, therefore a range of 200-300mg daily is recommended.
can it be applied topically?
Yes small amounts may be applied locally but remember at 200mg per ml it is highly concentrated with a single drop containing 10mg.
What is nanostilbene?
NanoStilbene is an easily absorbed nanoemulsion of nanoparticle pterostilbene in the range of 75-100nm at a concentration of 200 milligrams per milliliter
what is the concentration of nanostilbene?
NanoStilbene contains 200mg per ml or approximately 10mg per drop.
where can i obtain nanostilbene?
NanoStilbene can be obtained at our e-commerce site.